INTERROGATING THE SPATIOTEMPORAL LANDSCAPE OF NEUROMODULATORY GPCR SIGNALING BY REAL-TIME IMAGING OF CAMP IN INTACT NEURONS AND CIRCUITS

Interrogating the Spatiotemporal Landscape of Neuromodulatory GPCR Signaling by Real-Time Imaging of cAMP in Intact Neurons and Circuits

Summary: Modulation of neuronal circuits is key to information processing in the brain.The majority of neuromodulators exert their effects by activating G-protein-coupled receptors (GPCRs) that control the production of second messengers directly impacting cellular physiology.How numerous GPCRs integrate neuromodulatory inputs while accommodating d

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The energy landscape of magnetic materials

Abstract Magnetic materials can display many solutions to the electronic-structure problem, corresponding to different local or global minima of the energy functional.In Hartree-Fock or density-functional theory different single-determinant solutions lead to different magnetizations, ionic oxidation states, hybridizations, Posi-Clear RP Parts and i

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A Comparative Study between a Pseudo-Forward Equation (PFE) and Intelligence Methods for the Characterization of the North Sea Reservoir

This paper presents a comparative study between three Stacked Coffee Table versions of adaptive neuro-fuzzy inference system (ANFIS) algorithms and a pseudo-forward equation (PFE) to characterize the North Sea reservoir (F3 block) based on seismic data.According to the statistical studies, four attributes (energy, envelope, spectral decomposition a

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