Interrogating the Spatiotemporal Landscape of Neuromodulatory GPCR Signaling by Real-Time Imaging of cAMP in Intact Neurons and Circuits
Summary: Modulation of neuronal circuits is key to information processing in the brain.The majority of neuromodulators exert their effects by activating G-protein-coupled receptors (GPCRs) that control the production of second messengers directly impacting cellular physiology.How numerous GPCRs integrate neuromodulatory inputs while accommodating d